The HUM2N clinic’s founder, Dr. Mohammed Enayat, credits a regimen of vitamin B complex, magnesium, and omega-3 fatty acids with reversing his biological age. These supplements work by enhancing energy metabolism, regulating enzymatic processes, and combating inflammation, which collectively promote cellular vitality and resilience.
Key points
Vitamin B complex enhances energy metabolism, DNA repair, and nervous system function.
Magnesium regulates over 300 enzymatic reactions, improves sleep, and mitigates inflammation.
Omega-3 fatty acids (EPA/DHA) reduce systemic inflammation and support cardiovascular and brain health.
Why it matters:
This approach suggests affordable, non-invasive strategies can modulate cellular aging markers and inflammation, potentially transforming preventive healthcare and broadening therapeutic options in longevity research.
Q&A
What is biological age?
How do GlycanAge and TruAge tests work?
Why are B vitamins important for aging?
Can lifestyle changes replace supplements?
What role do senolytics have in longevity?
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Academy
Vitamin B Complex and Cellular Energy
Vitamin B complex comprises eight water-soluble vitamins (B1, B2, B3, B5, B6, B7, B9, B12) that act as cofactors in crucial metabolic pathways. These vitamins support ATP production in mitochondria, enable DNA synthesis and repair, and facilitate proper neurological function. Deficiencies in any B vitamin can lead to elevated homocysteine levels, impaired mood regulation, and accelerated cellular aging.
Foods rich in B vitamins include:
- Leafy greens (B9/folate)
- Whole grains and legumes (B1–B3)
- Eggs and dairy (B7, B12)
- Meat and fish (B6, B12)
Supplementation ensures consistent blood levels, especially for older adults with reduced absorption. It supports repair of oxidative DNA damage and improves metabolic resilience.
Magnesium: The Master Mineral
Magnesium is a cofactor for over 300 enzymes that regulate muscle and nerve function, blood glucose control, and blood pressure. It stabilizes ATP molecules, aids in protein synthesis, and modulates NMDA receptors in the brain to support cognition and sleep. Insufficient magnesium can cause chronic inflammation, impaired insulin sensitivity, and restless sleep—all factors that accelerate aging.
- Sources: nuts, seeds, whole grains, legumes, dark chocolate
- Recommended forms: magnesium citrate, glycinate, or malate
- Benefits: stress reduction, improved sleep, muscle recovery
Regular magnesium intake helps maintain cellular homeostasis, reduce oxidative stress, and protect against age-related metabolic disorders.
Omega-3 Fatty Acids in Healthy Aging
Omega-3 fatty acids, primarily EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), are polyunsaturated fats found in fish oils and certain plant seeds. These lipids incorporate into cell membranes, enhancing fluidity and signaling functions. They exert potent anti-inflammatory effects by competing with arachidonic acid pathways, thereby reducing cytokine production.
- Dietary sources: fatty fish (salmon, mackerel), chia seeds, flaxseeds, walnuts
- Supplement forms: fish oil capsules, algal oil for vegetarians
- Health impacts: cardiovascular protection, improved cognitive function, joint mobility
Supplementing with omega-3s can mitigate chronic inflammation, support neuroprotection, and improve lipid profiles—key aspects of a longevity-focused regimen.