Researchers at UCSF, under Dr. Dena Dubal and reported by Anna Drangowska-Way in April 2025, discovered that reactivation of the silent X chromosome in aged female mice’s hippocampi is linked to enhanced cognition. Using cross-strain experiments, they observed increased PLP1 expression, suggesting innovative intervention strategies for age-related cognitive decline.
Q&A
- How does reactivation of the silent X chromosome affect cognition?
- What is the significance of PLP1 in this study?
- How did the researchers isolate gene expression from the silent chromosome?