Researchers from Albert Einstein College revealed that rare IGF-1 gene variants in Ashkenazi centenarians lead to decreased receptor binding and lower IGF-1 levels. Their simulations suggest these mutations may dampen IGF-1 signaling, offering insights into the genetic foundations of exceptional longevity and healthy aging.
Q&A
- What is IGF-1 and its role in longevity?
- How were the variants identified in the study?
- What could be the implications of these findings?
