Researchers from News Medical, led by Hugo Francisco de Souza and reviewed by Susha Cheriyedath, discovered ultra-rare IGF-1 gene variants in Ashkenazi centenarians. These mutations decrease receptor signaling—similar to reducing harmful cellular activity—offering a promising example of how genetic factors can promote healthy aging and prevent common age-related diseases.
Q&A
- What is the role of IGF-1 in human aging?
- How do the identified gene variants affect longevity?
- What techniques were used to validate the findings?