Researchers at Longevity Science introduce a suite of precision-formulated anti-aging supplements that replenish NAD+ levels, activate sirtuins and support sleep and recovery. By leveraging peer-reviewed ingredients like NMN, Urolithin A, and Quercetin at optimized doses, the line addresses key cellular pathways to enhance healthspan and resilience.
Key points
NMN+ blend replenishes NAD+ and supports mitochondrial function for cellular energy.
Booster formulation utilizes Trans-Resveratrol, Quercetin and Spermidine to activate sirtuins and clear senescent cells.
Sleep Better supplement combines Ashwagandha, L-Theanine, and Magnesium Bisglycinate to enhance restorative sleep.
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Nicotinamide Mononucleotide (NMN): A Key NAD+ Precursor
Nicotinamide mononucleotide (NMN) is an essential molecule in the biosynthesis of nicotinamide adenine dinucleotide (NAD+), a coenzyme found in every living cell. NAD+ plays a critical role in cellular energy production by shuttling electrons during redox reactions in the mitochondria. As we age, NAD+ levels decline, leading to reduced mitochondrial efficiency and cellular energy deficits. NMN supplementation aims to restore NAD+ pools, supporting metabolic health, DNA repair mechanisms, and activation of longevity-associated enzymes called sirtuins.
NAD+ and Cellular Energy
The coenzyme NAD+ is central to energy metabolism, acting as an electron carrier in the tricarboxylic acid (TCA) cycle and oxidative phosphorylation. By accepting electrons from metabolic substrates, NAD+ drives ATP production, the primary energy currency of the cell. Adequate NAD+ levels also regulate signaling pathways that influence gene expression, stress responses, and aging processes. Boosting NAD+ through NMN or similar precursors can improve mitochondrial function, enhance endurance, and promote resilience against metabolic stress.
Senolytics and Cellular Senescence
Senescent cells accumulate with age and adopt a pro-inflammatory secretory profile that impairs tissue function. Senolytics are compounds designed to selectively eliminate these dysfunctional cells. Molecules like quercetin, fisetin, and urolithin A have demonstrated senolytic activity by triggering apoptosis in senescent cells without harming healthy cells. Clearing senescent cells can reduce chronic inflammation, improve regenerative capacity, and support overall tissue homeostasis, making senolytics a promising avenue in longevity science.
Adaptogens and Sleep Quality
Adaptogens such as Ashwagandha, N-acetylcysteine (NAC), and L-Theanine help the body adapt to physical and emotional stress by modulating the hypothalamic-pituitary-adrenal (HPA) axis. They reduce cortisol levels, promote relaxation, and facilitate deep, restorative sleep. Quality sleep is fundamental for cellular recovery, cognitive function, and hormone regulation. Incorporating adaptogens into a longevity regimen supports stress resilience, recovery after exercise, and emotional well-being.
Formulation Principles and Quality Standards
Longevity Method supplements are formulated based on peer-reviewed research to ensure bioavailability and efficacy. Standardized extraction processes, third-party testing, and adherence to Good Manufacturing Practices (GMP) guarantee product safety and consistency. Optimal dosing strategies consider pharmacokinetics and synergistic interactions between ingredients to maximize therapeutic potential.
Integrating Supplements into a Longevity Plan
- Assess individual health goals and consult a healthcare professional.
- Begin with foundational formulations like NMN+ for NAD+ support.
- Add targeted boosters (sirtuin activators, senolytics) according to specific needs.
- Monitor sleep quality and stress levels, adjusting adaptogens as necessary.
- Maintain a balanced diet and exercise regimen to complement supplement effects.
