Dermatology teams at leading institutions review how gerotherapeutics like rapamycin and ablative fractional lasers modulate aging pathways, reversing age-related molecular signatures in skin and potentially extending healthspan by integrating cosmetic and therapeutic strategies.

Key points

• Rapamycin analogs inhibit mTOR to extend lifespan and ameliorate age-related conditions, though high cost limits accessibility.
• Ablative fractional laser treatment reverses aging gene expression in skin, enhancing collagen synthesis and tissue regeneration via transcriptomic changes.
• Topical agents like 5-fluorouracil and retinoids mitigate photoaging and actinic keratoses, illustrating dual cosmetic and clinical utility.

Why it matters: Integrating cosmetic and clinical aging interventions in dermatology could redefine medical priorities, shifting focus toward healthspan extension and chronic disease prevention.