Vitruvin Longevity, a leading supplement developer, releases a stimulant-free, clean-label anti-aging formula designed to optimize NAD+ pathways, support mitochondrial performance and promote cellular repair. By combining high-purity botanical extracts, bioavailable cofactors and adaptogens, the supplement delivers daily resilience against oxidative stress and cognitive decline, offering health-conscious adults a transparent, integrative approach to longevity.
Key points
Integrates NAD+ precursors and mitochondrial cofactors in a bioavailable, stimulant-free formula to support cellular energy metabolism.
Includes adaptogenic botanicals and antioxidants to modulate oxidative stress and promote cellular repair pathways.
Employs full-disclosure dosing strategy for ingredient transparency, facilitating safe stacking and informed longevity regimens.
Why it matters:
Vitruvin Longevity's transparent, multi-pathway formula offers a more precise and integrative alternative to conventional proprietary anti-aging blends.
Q&A
What is NAD+ and why is it important?
How does mitochondrial support impact aging?
What does clean-label mean in supplements?
Can I stack Vitruvin Longevity with other supplements?
Read full article
Academy
NAD+ in Cellular Metabolism
NAD+ (nicotinamide adenine dinucleotide) is a vital coenzyme involved in hundreds of metabolic pathways. It serves as an electron carrier in redox reactions, cycling between oxidized (NAD+) and reduced (NADH) forms. In mitochondria, NAD+ accepts electrons from metabolic intermediates during the citric acid cycle and transfers them to the electron transport chain to produce ATP, the cell’s main energy currency. Adequate NAD+ levels are critical for sustaining energy production, regulating stress responses and promoting DNA repair processes.
By age 40, cellular NAD+ concentrations often decline by as much as 50%, impairing mitochondrial function and increasing susceptibility to oxidative damage. Restoring NAD+ through precursors such as nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN) has emerged as a promising strategy in longevity science. These precursors enter salvage pathways that efficiently regenerate NAD+, supporting sirtuin enzymes that regulate gene expression, mitochondrial biogenesis and inflammatory responses.
Mitochondrial Function and Aging
Mitochondria are dynamic organelles that produce cellular energy, regulate apoptosis (programmed cell death) and generate metabolites for biosynthetic processes. With age, mitochondrial DNA mutations accumulate and membrane potential declines, leading to reduced ATP output and increased reactive oxygen species (ROS) production. Elevated ROS can damage proteins, lipids and nucleic acids, exacerbating cellular aging.
Strategies to support mitochondrial health include:
- Supplementing mitochondrial cofactors (e.g., Coenzyme Q10, alpha-lipoic acid) to optimize electron transport and reduce ROS leakage.
- Incorporating antioxidants (e.g., polyphenols, astaxanthin) that neutralize free radicals and protect mitochondrial membranes.
- Promoting mitochondrial biogenesis through activation of sirtuin 1 (SIRT1) and PGC-1α pathways, often stimulated by NAD+ levels.
- Implementing lifestyle measures such as intermittent fasting and high-intensity interval training, which can trigger mitophagy, the selective removal of damaged mitochondria.
Combining NAD+ restoration with targeted mitochondrial support provides a synergistic approach to maintaining cellular energy homeostasis, reducing oxidative stress and preserving organ function. This multi-pathway framework underpins many anti-aging supplement formulations aimed at enhancing resilience and promoting healthy longevity.
