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Enteric-Coated Capsules in Nutrient Delivery

Definition: Enteric coating is a specialized protective layer applied to oral capsules or tablets that resists disintegration in the acidic environment of the stomach. Instead, it dissolves in the higher-pH environment of the small intestine, ensuring that sensitive active ingredients reach their target site intact.

How It Works: Most enteric coatings are made from pH-sensitive polymers, such as methacrylic acid copolymers, which remain stable at a pH below 5.5. When the capsule passes into the small intestine, where the pH typically ranges from 6.5 to 7.5, the coating dissolves and releases the nutrient payload. This mechanism protects acid-labile compounds and minimizes gastric irritation.

• Enhanced Bioavailability: Preserves active ingredients from stomach acid degradation.
• Targeted Release: Delivers nutrients directly to the small intestine for optimal absorption.
• Reduced Gastrointestinal Discomfort: Limits irritation caused by direct exposure of sensitive compounds to the stomach lining.

• Manufacturing Complexity: Requires specialized equipment and quality control to ensure consistent coating thickness.
• Cost Factor: Typically increases production costs compared to standard capsules.
• Dosing Schedule: Some nutrients may be better absorbed with food; enteric-coated forms should balance protection and bioavailability.

Understanding NMN and NAD+ in Longevity

NAD+ Role: Nicotinamide adenine dinucleotide (NAD+) is a critical coenzyme in redox reactions, mitochondrial energy production and DNA repair pathways. Cellular NAD+ levels naturally decline with age, contributing to reduced metabolic efficiency and genomic instability.

NMN as a Precursor: Nicotinamide mononucleotide (NMN) is a direct biosynthetic precursor to NAD+. When ingested, NMN is converted into NAD+ within cells, helping to replenish intracellular pools and support key enzymatic processes.

1. Source and Safety: NMN appears naturally in trace amounts in certain foods and has been evaluated in safety studies at clinical dosages.
2. Mechanism of Action: NMN enters cells via specific transporters, is converted to NAD+, and fuels sirtuin-mediated DNA repair and mitochondrial function.
3. Synergistic Support: Pairing NMN with other antioxidants (e.g., Resveratrol, Selenium) and mitochondrial cofactors (e.g., CoQ10) can amplify cellular resilience.

By integrating enteric-coated NMN and complementary longevity nutrients, formulations like Longevity+ aim to overcome traditional absorption barriers and provide a streamlined approach to supporting healthy aging.