Longevity Method debuts Live Longer NMN+, a precision NMN-based formula that replenishes NAD⁺, enhances mitochondrial function, and synergizes with Urolithin A, TMG, and Ca-AKG to combat age-related cellular decline.
Key points
Live Longer NMN+ delivers Nicotinamide Mononucleotide to restore NAD⁺ levels and improve mitochondrial energy production.
Formulation includes Urolithin A to activate mitophagy and remove damaged mitochondria, enhancing cellular resilience.
Trimethylglycine and Calcium Alpha-Ketoglutarate support methylation balance and TCA cycle metabolism to optimize anti-aging pathways.
Why it matters:
By integrating NAD⁺ replenishment with mitophagy and metabolic support, Live Longer NMN+ offers a multifaceted strategy to slow cellular aging and enhance longevity.
Q&A
What is NMN and why is it important?
How does Urolithin A enhance mitochondrial health?
What role does Trimethylglycine (TMG) play in this formula?
Why include Calcium Alpha-Ketoglutarate (Ca-AKG)?
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Academy
Understanding NAD+, NMN, and Cellular Longevity
Nicotinamide Adenine Dinucleotide (NAD+) is a vital coenzyme found in every living cell. It drives key reactions in energy metabolism, particularly in the mitochondria, where it helps convert nutrients into cellular fuel (ATP). As we age, NAD+ levels naturally decline, leading to reduced energy production, impaired DNA repair, and increased oxidative stress. Maintaining healthy NAD+ concentrations is therefore central to supporting cellular health and slowing age-related functional decline.
Role of Nicotinamide Mononucleotide (NMN)
Nicotinamide Mononucleotide (NMN) is a direct precursor to NAD+. When ingested, NMN enters the cell and is converted into NAD+ through enzymatic pathways. This supplementation strategy bypasses rate-limiting steps in the NAD+ salvage pathway, making it an efficient method to restore NAD+ pools. By boosting NAD+, NMN supports critical processes such as energy metabolism, mitochondrial function, and genomic stability—key determinants of cellular longevity.
Synergy with Methylation Support: Trimethylglycine (TMG)
Trimethylglycine (TMG), also called betaine, donates methyl groups needed for various biochemical reactions, including those required for NAD+ synthesis. During the conversion of NMN to NAD+, methylation reactions consume methyl donors. Insufficient methyl groups can compromise DNA repair and gene regulation. Including TMG ensures balanced methylation, safeguarding genomic integrity and optimizing NAD+ production without disrupting other methyl-dependent cellular functions.
Boosting Mitophagy: Urolithin A
Urolithin A is a metabolite produced by gut bacteria from dietary polyphenols. It stimulates mitophagy—the selective removal of damaged or dysfunctional mitochondria. By clearing out unhealthy mitochondria and promoting the generation of new ones, Urolithin A enhances overall mitochondrial efficiency. When combined with NAD+ restoration from NMN, this dual approach significantly improves cellular energy output and resilience.
Enhancing Energy Metabolism: Calcium Alpha-Ketoglutarate (Ca-AKG)
Calcium Alpha-Ketoglutarate (Ca-AKG) is an intermediate in the tricarboxylic acid (TCA) cycle (also known as the Krebs cycle). It supports mitochondrial energy production and reduces inflammation. By providing Ca-AKG alongside NMN and Urolithin A, the TCA cycle receives key anaplerotic support, leading to increased ATP generation and enhanced metabolic health—critical factors in anti-aging interventions.
Comprehensive Longevity Strategy
Together, NMN, TMG, Urolithin A, and Ca-AKG form a multifaceted approach to cellular longevity. This combination addresses declining NAD+ levels, methylation balance, mitochondrial quality control, and energy metabolism. By supporting these interconnected pathways, individuals can promote healthier aging, improve energy levels, and maintain cellular function well into later life.