NeuroNexus and Blackrock Neurotech, in collaboration with Imec, employ flexible polymer substrates and MEMS-based processes to fabricate multifunctional neural microprobes capable of high-density recording and targeted stimulation. They integrate thin-film coatings and two-photon polymerization to enhance biocompatibility and mechanical compliance, aiming to improve chronic implantation stability and expand applications in neuromodulation therapies and brain-computer interfaces.

Key points

• Flexible polyimide and parylene C substrates reduce tissue damage for chronic neural interfacing.
• Two-photon polymerization and MEMS techniques yield customizable, high-density probe architectures with integrated microfluidics.
• PEDOT:PSS coatings and embedded AI microcontrollers deliver low-impedance recording, real-time processing, and closed-loop stimulation.

Why it matters: These flexible AI-enabled microprobes shift paradigms by uniting high-density interfacing with chronic reliability, enabling precise closed-loop neurotherapies.