Academy

Cellular Rejuvenation in Longevity Science

Overview: Cellular rejuvenation is an emerging field aimed at reversing molecular and functional hallmarks of aging in human cells. By understanding and manipulating genetic, epigenetic, and metabolic pathways, scientists seek to restore aged cells to a more youthful state, thereby extending tissue function and delaying age‐related diseases.

Key Concepts

• Induced Pluripotent Stem Cells (iPSCs): Adult cells reprogrammed to a stem‐cell‐like state, capable of differentiating into various cell types. They serve as a controlled model to study aging and rejuvenation mechanisms.
• CRISPR Screening: A genome-editing technique that systematically knocks out or modifies genes across the genome. High-throughput CRISPR screens identify genetic regulators of aging by observing which gene edits accelerate or reverse cellular aging phenotypes.
• Biological Age Metrics: Quantitative measures of cellular age based on molecular or imaging biomarkers. Examples include epigenetic clocks, transcriptomic signatures, and AI-driven image analysis (e.g., imAge).
• Rejuvenation Pathways: Cellular processes—such as improved mitochondrial function, enhanced DNA repair, and proteostasis maintenance—that, when modulated, can restore youthful cell characteristics.

Rejuvenation Technologies

1. geneAge Atlas: A comprehensive map of genetic targets controlling cellular aging, generated through genome-wide CRISPR screening in human iPSCs.
2. imAge AI Imaging: An AI-enabled platform that analyzes single-cell images to estimate biological age, enabling rapid phenotypic screening of rejuvenation interventions.
3. Adaptive Clinical Engines: Innovative trial designs that allow for rapid, data-driven adjustments during human studies, accelerating validation of topical and nutraceutical therapies.

Applications in Longevity

By decoding the genetic programs of aging and applying AI-driven quantification, researchers can develop targeted treatments—ranging from skin creams to oral supplements—that demonstrate measurable age reversal. Early human data from topical and nutraceutical trials build confidence and guide the path toward systemic rejuvenation therapies.

Future Directions

Ongoing research aims to expand rejuvenation targets beyond skin and nutrition to systemic regenerative treatments. Integrating multi-omics data (genomics, epigenomics, proteomics) with AI-driven analytics promises refined interventions for age-related diseases such as neurodegeneration, cardiovascular decline, and metabolic disorders.