Cymbiotika’s formulators introduce an advanced dietary supplement combining Nicotinamide Mononucleotide (NMN), Trans-Resveratrol, Apigenin, and Green Coffee Bean Extract. This blend enhances NAD+ biosynthesis, triggers sirtuin activation, and reduces NAD+ degradation to support cellular metabolism. It uses synergistic antioxidants and absorption boosters to improve energy production, mental clarity, and vital functions, catering to individuals pursuing longevity and metabolic health in a scientifically informed wellness regimen.
Key points
Proprietary blend delivers 250mg NMN with 50mg Trans-Resveratrol per serving to enhance NAD+ biosynthesis and sirtuin activation.
Apigenin’s CD38 inhibition and chlorogenic acids from Green Coffee Bean Extract optimize NAD+ preservation and compound bioavailability.
Third-party tested, vegan formula supports improved energy, cognitive clarity, and sleep quality in healthy adult users.
Why it matters:
By integrating synergistic compounds to sustain NAD+ levels and sirtuin function, this supplement exemplifies a multi‐targeted approach that could enhance cellular vitality and inform future anti‐aging therapeutics.
Q&A
What role does NAD+ play in cellular metabolism?
How does Apigenin inhibit CD38?
Why is third-party testing important for supplements?
Can NMN and Resveratrol interact with medications?
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Academy
NAD+ and NMN: Foundations of Cellular Energy and Longevity
Introduction: Cellular health and energy production decline with age, driven in part by reduced levels of nicotinamide adenine dinucleotide (NAD+), a coenzyme essential for metabolism, DNA repair, and signaling. Researchers and supplement formulators have focused on restoring NAD+ via precursors such as nicotinamide mononucleotide (NMN). This course module explores NAD+ biology, NMN supplementation, and their relevance to longevity science.
The Role of NAD+ in Cellular Metabolism
NAD+ functions as a critical electron carrier in metabolic pathways that convert nutrients into energy. In the mitochondria, NAD+ accepts electrons during the citric acid cycle and transfers them to the electron transport chain, driving adenosine triphosphate (ATP) production. NAD+ is also a substrate for enzymes such as sirtuins and poly(ADP-ribose) polymerases (PARPs) that regulate gene expression, stress responses, and DNA repair.
- Energy Conversion: NAD+ accepts electrons from metabolic intermediates, cycling between oxidized (NAD+) and reduced (NADH) forms to power ATP synthesis.
- Enzymatic Signaling: Sirtuins use NAD+ to remove acetyl groups from proteins, affecting gene regulation and mitochondrial function.
- Genome Maintenance: PARP enzymes consume NAD+ to repair DNA breaks, preserving genomic integrity.
NMN as a Precursor to NAD+
NMN is a direct intermediate in the NAD+ biosynthesis pathway, derived from vitamin B3 forms. Oral NMN supplementation raises intracellular NAD+ by entering cells through specialized transporters and converting to NAD+ via enzymatic cascades. Studies in animals suggest NMN can improve insulin sensitivity, boost energy levels, and enhance mitochondrial health. Human trials are ongoing, but preliminary findings support NMN’s role in elevating NAD+.
- NMN Absorption: Specialized transporters facilitate NMN uptake into cells.
- Enzymatic Conversion: NMN is converted to NAD+ by NMN adenylyltransferases.
- Bioavailability Enhancers: Ingredients like green coffee bean extract can improve absorption and stability.
Implications for Longevity Science
By restoring NAD+ pools, NMN supplementation aims to counteract age-related declines in energy metabolism and cellular repair. Enhanced sirtuin activity can lead to improved mitochondrial function, stress resistance, and gene regulation. While no supplement reverses aging, strategies that maintain NAD+ support healthy aging trajectories and may delay the onset of metabolic and neurodegenerative disorders.
Safety, Dosage, and Best Practices
NMN and related compounds are generally well tolerated at recommended doses (typically 250–500mg daily). Potential side effects include mild digestive discomfort or headache during initial use. Formulations may include CD38 inhibitors like Apigenin to preserve NAD+ and antioxidants to mitigate oxidative stress. Always consult a healthcare professional before beginning NMN supplementation, especially when taking other medications.
This module provides foundational knowledge for longevity enthusiasts seeking to understand NAD+ biology and the scientific basis for NMN use in anti-aging strategies.
