At the INNOCOS Beauty & Longevity Summit, experts from brands like SYSTEM SKIN and 111SKIN present an integrative model that fuses topical care, ingestibles, biomarker testing, and AI-driven platforms to optimize aging pathways and extend healthspan.
Key points
Integrative platforms combine topical products, supplements, diagnostics and AI for multi-pathway aging interventions
Biometric testing—saliva, blood, microbiome—drives precision beauty regimens via companion apps
Postbiotic urolithin A and biotech peptides/exosomes target mitophagy and cellular repair for enhanced healthspan
Why it matters:
This integrative shift merges systemic health insights with personalized beauty, setting a new standard for proactive, data-driven longevity solutions.
Q&A
What is integrative longevity?
How does biomarker testing personalize beauty routines?
What are postbiotics and why are they important?
Why are peptides and exosomes considered pro-longevity?
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Academy
Postbiotics and Mitochondrial Health: A Guide for Longevity Enthusiasts
Postbiotics are compounds produced by beneficial gut bacteria during the fermentation of dietary fibers and polyphenols. Unlike probiotics, which introduce live microbes, postbiotics deliver the bioactive molecules that already carry health-promoting properties. These include short-chain fatty acids, peptides, enzymes and microbial metabolites such as urolithin A. In longevity science, postbiotics have gained attention for their roles in supporting mitochondrial function and promoting mitophagy, the cellular process of recycling damaged mitochondria.
Mitochondria are organelles found inside nearly every human cell. They generate the energy currency of the cell—adenosine triphosphate (ATP)—through a process called oxidative phosphorylation. Over time, however, mitochondria can become damaged by reactive oxygen species, environmental stressors and natural aging processes. Mitophagy is the quality-control mechanism that identifies and recycles these impaired mitochondria, maintaining cellular energy output and reducing oxidative stress.
Research into urolithin A, a postbiotic derived from pomegranate metabolites, has demonstrated its ability to stimulate mitophagy, protect mitochondrial efficiency and improve muscle function in preclinical models. Human trials show improved endurance and cellular energy markers in participants receiving urolithin A supplements. Because only some people naturally produce urolithin A from dietary polyphenols, targeted supplementation offers a reliable route to tapping this longevity pathway.
Key Benefits of Postbiotic Mitochondrial Support:
- Enhanced Cellular Energy: By clearing damaged mitochondria, cells sustain robust ATP production.
- Reduced Oxidative Stress: Mitophagy reduces reactive oxygen species that damage DNA and proteins.
- Skin Health Improvement: Supporting mitochondrial function contributes to collagen synthesis, barrier function and tissue repair.
- Gut–Skin–Brain Axis: Postbiotics modulate inflammation and signaling molecules that affect mood, cognition and dermal health.
Sources and Supplementation Strategies
Dietary sources of urolithin A precursors include pomegranate, berries and nuts. However, microbial conversion rates vary widely by individual microbiome composition. Specialized supplements containing purified urolithin A or fermented extracts can bypass this variability, delivering consistent doses. When selecting a product, look for clinical-grade formulations that specify dosage, purity, and evidence of mitophagy activation.
Integrating Postbiotics into Your Routine
- Consult a healthcare practitioner to assess baseline mitochondrial markers or inflammatory profiles via blood or saliva tests.
- Select a postbiotic supplement from a reputable brand, verifying third-party quality and clinical data.
- Combine with lifestyle interventions—regular exercise, balanced nutrition and sleep hygiene—to maximize mitochondrial resilience.
- Monitor progress through biomarker testing apps or wearable devices that track energy metrics, inflammation markers and skin parameters.
By understanding and leveraging postbiotics for mitochondrial health, longevity enthusiasts can adopt a science-backed strategy to enhance both internal vitality and external glow—making sustainable beauty and wellness a unified journey.
