International research teams evaluate fifteen scientific approaches, including telomere modulation, senolytic drug removal of senescent cells, CRISPR gene editing, and nanomedical cellular repair, analyzing each method’s mechanism and therapeutic potential against age-related degeneration.

Key points

• Telomerase activation in aged mice restores telomere length but raises oncogenic cancer risk.
• Dasatinib and quercetin senolytics clear senescent cells, improving healthspan and extending lifespan in murine models.
• CRISPR base editing corrects progeria mutations, enhancing nuclear stability and doubling survival in mice.

Why it matters: This synthesis illuminates transformative strategies for reversing aging hallmarks, paving the way for novel, clinically viable longevity therapies.