Cambridge-based biotech clock.bio decodes an Atlas of Rejuvenation Factors by aging induced pluripotent stem cells with CRISPR and single-cell RNA sequencing. The team pinpoints 100+ genes driving cellular self-repair to guide multi-pathway therapies against degenerative diseases.

Key points

• CRISPR screens in human iPSCs identify >100 genes driving cellular self-repair.
• Single-cell RNA sequencing analyzes 3 million cells to map transcriptomic rejuvenation pathways.
• 23% of targets link to FDA-approved drugs, enabling rapid therapeutic repurposing.

Why it matters: This genetic atlas shifts aging research from correlation to causal gene targets, accelerating precision therapies for multiple age-related conditions.