A coalition of international research teams is advancing fifteen diverse strategies, including telomere extension, senolytics, CRISPR gene editing, digital immortality, and whole-body vitrification. These approaches employ genetic therapies, nanoparticle drug delivery, and neural interfaces to decelerate cellular aging, eliminate senescent cells, and safeguard consciousness, with the overarching goal of extending healthspan and overcoming age-related pathologies.

Key points

• Telomerase gene therapy extends cellular lifespan by up to 40% in human fibroblasts via targeted telomere elongation.
• Senolytic combination of dasatinib and quercetin clears over 90% of senescent cells in aged mice, restoring cardiac and physical function.
• CRISPR-Cas9 editing of longevity-associated genes in mouse models reduces age-related pathology and boosts median lifespan by 15%.

Why it matters: This overview of multi-modal longevity technologies highlights transformative therapies that could redefine healthspan and expand human lifespan.

International research teams evaluate fifteen scientific approaches, including telomere modulation, senolytic drug removal of senescent cells, CRISPR gene editing, and nanomedical cellular repair, analyzing each method’s mechanism and therapeutic potential against age-related degeneration.

Key points

• Telomerase activation in aged mice restores telomere length but raises oncogenic cancer risk.
• Dasatinib and quercetin senolytics clear senescent cells, improving healthspan and extending lifespan in murine models.
• CRISPR base editing corrects progeria mutations, enhancing nuclear stability and doubling survival in mice.

Why it matters: This synthesis illuminates transformative strategies for reversing aging hallmarks, paving the way for novel, clinically viable longevity therapies.