The HUM2N clinic’s founder, Dr. Mohammed Enayat, credits a regimen of vitamin B complex, magnesium, and omega-3 fatty acids with reversing his biological age. These supplements work by enhancing energy metabolism, regulating enzymatic processes, and combating inflammation, which collectively promote cellular vitality and resilience.

Key points

• Vitamin B complex enhances energy metabolism, DNA repair, and nervous system function.
• Magnesium regulates over 300 enzymatic reactions, improves sleep, and mitigates inflammation.
• Omega-3 fatty acids (EPA/DHA) reduce systemic inflammation and support cardiovascular and brain health.

Why it matters: This approach suggests affordable, non-invasive strategies can modulate cellular aging markers and inflammation, potentially transforming preventive healthcare and broadening therapeutic options in longevity research.

A multidisciplinary team investigates biohacking strategies—nutrigenomics, advanced supplementation, stem cell therapies, gene editing, and AI-driven personalised medicine—to modulate aging pathways, aiming to extend healthspan and mitigate age-associated diseases through integrated technological interventions.

Key points

• Nutrigenomics-driven dietary strategies target gene–nutrient interactions to regulate aging-related pathways.
• Senolytic compounds and NAD+ precursors clear senescent cells and restore cellular energy for improved function.
• CRISPR gene therapy combined with AI analytics enables personalised editing and prediction of longevity outcomes.

Why it matters: Integrating genomics, AI, and regenerative techniques could shift aging interventions from trial-and-error supplementation to precision-based longevity therapies with broader disease prevention impact.

A team of Chinese scientists investigates metformin’s potential as an anti-aging intervention by examining its effects on cellular energy regulation and organ protection in both human cohorts and primate models. They report a 30% reduction in mortality before age 90 among postmenopausal women, and demonstrate metformin activates AMPK pathways to mitigate inflammation, protect vital tissues, and enhance metabolic resilience against age-related diseases.

Key points

• 30% reduction in mortality risk before age 90 among postmenopausal women in epidemiological analysis.
• Metformin activates AMPK to reduce inflammation and improve insulin sensitivity.
• Primate studies show organ protection and slowed brain aging via AMPK-driven gene activation.

Why it matters: By targeting aging processes rather than individual diseases, metformin offers a scalable strategy to prevent multiple age-related disorders and extend healthspan.

The Vatican Longevity Summit in Rome brought experts including Nobel laureates to examine ethical and technical advances for healthy aging. Discussions emphasized intergenerational dialogue and technology-driven healthcare reforms, providing practical policy examples to enhance equity and wellness.