Anjan Chatterjee MD, FAAN, of the University of Pennsylvania surveys recent breakthroughs in longevity science, including epigenetic modulation, gene editing, cellular senescence reprogramming, stem-cell regeneration, and pharmacological interventions like metformin and rapamycin. The article also critically evaluates potential socioeconomic inequities, geopolitical consequences, and the distinction between lifespan extension and eudaimonic well-being.

Key points

• Epigenetic modifications: CRISPR and small-molecule epigenetic modulators reverse age-related chromatin changes in rodent and human cell assays, improving genomic stability metrics.
• Senolytics and reprogramming: Rapamycin and metformin treatments in aged mice clear senescent cells and restore tissue function, measured by mobility and organ-specific biomarkers.
• Stem-cell regeneration: Autologous stem-cell transplants and young plasma factors enhance regenerative capacity in preclinical models, quantified by increased tissue repair rates and reduced inflammatory markers.

Why it matters: Prioritizing lifespan extension without addressing ethical, economic, and quality-of-life dimensions risks exacerbating inequities and undermining genuine human flourishing.

A 2022 study by Eric S. Kim highlights that a strong purpose reduces mortality by 46% and enhances cognitive function. In his Psychology Today piece, Ali Mostashari, Ph.D. demonstrates that purpose planning is vital for sustained wellness and active living.