Multiple research teams present evidence that Niagen, a nicotinamide riboside precursor to NAD+, accelerates cellular NAD+ synthesis, enhancing DNA repair mechanisms, mitochondrial efficiency, and sirtuin activation. These effects translate into potential benefits against cognitive decline, metabolic dysfunction, cardiovascular stiffness, and muscle wastage. Human and animal studies indicate that daily supplementation of 250–300 mg is safe and effective at elevating systemic NAD+ levels, making Niagen a promising candidate for longevity interventions.

Key points

• Niagen (nicotinamide riboside) elevates NAD+ by up to 2.7× in rodent models.
• Boosted NAD+ activates SIRT1 and PARP enzymes, enhancing DNA repair and mitochondrial function.
• Daily supplementation of 250–300 mg demonstrates safety and significant systemic NAD+ increases in human studies.

Why it matters: Niagen’s ability to replenish NAD+ offers a promising therapeutic strategy for addressing age-related cellular decline and metabolic disorders.