Bryan Johnson’s Blueprint program blends nutritional flavonols from pure cocoa with gene therapy, rapamycin, supplements, and targeted cosmetic treatments in a rigorous regimen designed to rewind biological age by enhancing cellular repair and reducing senescence.

Key points

• Ultra-pure high-flavonol cocoa intake reduces oxidative stress and supports cardiovascular and neuroprotective pathways.
• AAV-mediated Follistatin gene therapy inhibits myostatin to increase muscle mass and mitigate age-related sarcopenia.
• Integrated rapamycin dosing, plasma transfusions, and shockwave therapy with strict diet and exercise yields organ-level biological age reversal.

Why it matters: Combining dietary flavonols with targeted molecular therapies demonstrates a viable, multi-pronged strategy for measurable reversal of biological aging in humans.