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The aestheticsadvisor.com Editorial Team reviews over a thousand clinical studies to rank the ten most promising nutraceuticals for longevity—from vitamin D3 and omega-3s to glycine and CoQ10. They describe each supplement’s mechanism of action, research evidence, and role in targeting aging pathways.

Key points

  • Vitamin D3 and omega-3 co-supplementation preserves telomere integrity and reduces cancer risk in the VITAL trial.
  • GlyNAC (glycine + NAC) restores glutathione, improves mitochondrial function, and reduces oxidative stress in older adults.
  • CoQ10/PQQ and molecular hydrogen synergistically enhance mitochondrial biogenesis, ATP production, and antioxidant defenses.

Why it matters: This multi-targeted supplement framework underscores a shift toward precision geroscience, offering potential synergy across aging hallmarks.

Q&A

  • Why combine vitamin D3 with omega-3 fatty acids?
  • What is GlyNAC and how does it work?
  • How does molecular hydrogen act as an antioxidant?
  • Why use both CoQ10 and PQQ for mitochondrial support?
  • How does collagen supplementation improve skin health?
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