Shift Bioscience uses a dataset-driven approach to pinpoint SB000, a novel single-gene target that reverses aging at both methylome and transcriptome levels across multiple cell types, while sidestepping dangerous pluripotency pathways triggered by Yamanaka Factors.

Key points

• SB000 reverses cellular aging without activating pluripotency pathways associated with tumorigenesis
• Dataset-driven discovery yields methylome rejuvenation comparable to OSKM across multiple human cell types
• Single-gene SB000 target advances safer next-generation cellular rejuvenation therapeutics

Why it matters: The identification of SB000 enables a safer route to cellular rejuvenation, overcoming OSKM-induced tumorigenicity concerns.