Leading aesthetic medicine clinics are now employing advanced injectable compounds—including polynucleotides, exosomes, and bioidentical hormone peptides—to stimulate collagen synthesis, enhance elastin production, and restore facial volume. Through targeted intradermal administration, these interventions promote skin regeneration and hydration more effectively than traditional neuromodulators. This multifaceted approach addresses age-related dermal decline for individuals over 60.

Key points

• Polynucleotide injections activate dermal fibroblasts, increasing collagen and elastin synthesis for firmer skin.
• Exosome formulations deliver growth factors and genetic signals to enhance cellular repair and reduce inflammation.
• Calcium hydroxylapatite-based collagen stimulators provide gradual, long-lasting volumization through endogenous extracellular matrix remodeling.

Why it matters: These injectable innovations could redefine non-surgical dermatology by offering longer-lasting, more natural collagen regeneration compared to traditional neuromodulators.