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The Salk Institute team uses a viral vector encoding four reprogramming factors to rejuvenate aging mouse cells, achieving a 30% lifespan increase by reversing cellular senescence. Concurrently, Life Biosciences plans human trials targeting optic nerve damage in NAION using similar gene rejuvenation methods.

Key points

  • Polyviral vector delivers Yamanaka factors (Oct4, Sox2, Klf4, c-Myc) to aged mice, extending lifespan by 30%.
  • Life Biosciences collaborates with Harvard researchers for first human gene rejuvenation trials targeting NAION via ocular injections.
  • Complementary longevity strategies include senolytic drugs to clear senescent cells and telomere-lengthening approaches, each with unique safety profiles.

Why it matters: This work demonstrates direct cellular reprogramming as a viable strategy for aging intervention, paving the way for therapies that restore tissue function rather than merely managing symptoms.

Q&A

  • What are Yamanaka factors?
  • What is non-arteritic anterior ischemic optic neuropathy (NAION)?
  • How do senolytics contribute to longevity research?
  • Why are teratomas a concern in cellular reprogramming?
  • What distinguishes radical longevity from healthspan research?
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Radical Longevity, Healthspan: The Road Ahead (2 of 3)