Researchers at institutions including Mount Sinai Health System, UT Health San Antonio, and UCSD’s Stein Institute identify lifestyle and pharmacological strategies—regular exercise, Mediterranean diet, and clinical trials of metformin and rapamycin—that modulate inflammation and enhance immune resilience. These approaches aim not merely to extend lifespan but to optimize healthspan, maintaining robust physiological function and reducing chronic disease burden in older adults.
Key points
- Regular physical exercise reduces cardiovascular, metabolic, and neurodegenerative risks by modulating inflammatory cytokine profiles across all ages.
- Mediterranean diet rich in fruits, vegetables, whole grains, legumes, and olive oil outperforms other diets in clinical trials for prolonging life and lowering cardiovascular risk in at-risk populations.
- Metformin and rapamycin trials leverage AMPK activation and mTOR inhibition to attenuate senescence-associated inflammation and enhance immune resilience in older adults.
Why it matters: Targeting inflammation and immune resilience through lifestyle and drug interventions could shift aging paradigms and reduce chronic disease burdens.
Q&A
- What distinguishes healthspan from lifespan?
- How does the Mediterranean diet contribute to healthy aging?
- What is immune resilience in the context of aging?
- What evidence supports metformin and rapamycin for longevity?