Precision Nutrition outlines practical biomarker tests—from grip strength and balance assessments to clinical blood panels and DNA methylation clocks—to measure biological age. By tracking these markers, individuals can quantify healthspan progress and tailor interventions to decelerate aging.

Key points

• Free field tests (Sitting-Rising, grip strength, single-leg stance) assess functional aging markers.
• Clinical diagnostics (blood panels, DEXA bone density) track cardiovascular risk and skeletal health.
• Advanced molecular clocks (DNA methylation, telomere length) quantify cellular aging at the epigenetic level.

Why it matters: Accurate, accessible biomarkers offer a holistic view of physiological aging, enabling timely interventions to extend healthspan and personalize longevity strategies.

Drawing on work at the University of Sheffield’s Healthy Lifespan Institute and USC’s Longevity Institute, experts highlight the benefits of moderate evening resistance and cardio exercise finished 90 minutes before sleep, plant-forward meals timed three hours before bedtime, and a stable 10–11pm lights-out schedule to optimize metabolic health and longevity.

Key points

• Moderate evening resistance and aerobic exercise, finished ≥90 minutes before sleep, reduces premature mortality risk by 20–30% and enhances deep sleep stages.
• Plant-rich dinners high in fiber and lean protein, consumed three hours before bedtime, stabilize blood sugar and lower obesity and diabetes risk.
• Consistent 10–11 pm sleep onset, combined with dimmed lights and caffeine avoidance, aligns circadian rhythms to reduce cardiovascular disease rates.

Why it matters: Integrating circadian-aligned exercise, nutrition, and sleep routines offers a scalable strategy to prevent age-related disease and promote healthy aging.

Scientists at the SENS Research Foundation combine telomerase therapy, senolytics, stem cell treatments, and rapamycin in a controlled mouse experiment to target key aging damage pathways, demonstrating additive lifespan benefits and paving the way for scalable anti-aging strategies.

Key points

• Eight-component protocol targets all seven SENS damage categories in middle-aged mice.
• Combination of telomerase gene therapy, senolytics, stem cell transplant and rapamycin yields additive lifespan extension.
• New additions—partial reprogramming, GDNF, IL-11 inhibition, astaxanthin—broaden damage coverage.

Why it matters: Combining multiple targeted therapies to repair aging damage shifts the paradigm from disease treatment to comprehensive rejuvenation, enabling impactful longevity interventions.

Investigators at Peking Union Medical College Hospital conduct a national cross-sectional survey among 456 Chinese critical care academic physicians to evaluate Generative AI adoption in standardized residency training. They report that 64.7% use AI clinically and 33.1% in teaching, primarily for content generation and simulation, while highlighting ethical concerns such as over-reliance and data privacy. Respondents endorse enhanced AI training and ethics education to support effective, equitable integration in medical education.

Key points

• Nationwide survey of 456 critical care academic physicians using a Wenjuanxing questionnaire to assess Generative AI usage.
• Logistic regression shows clinical AI use predicts teaching adoption (adjusted OR 1.59, 95% CI 1.06–2.38, p=0.0239).
• Top teaching applications: querying pedagogical content (79.5%) and generating instructional materials (65.6%).

Why it matters: This study clarifies critical care educators’ AI adoption behaviors and ethics priorities, guiding responsible integration of AI in medical training.