A coalition of international research teams is advancing fifteen diverse strategies, including telomere extension, senolytics, CRISPR gene editing, digital immortality, and whole-body vitrification. These approaches employ genetic therapies, nanoparticle drug delivery, and neural interfaces to decelerate cellular aging, eliminate senescent cells, and safeguard consciousness, with the overarching goal of extending healthspan and overcoming age-related pathologies.

Key points

• Telomerase gene therapy extends cellular lifespan by up to 40% in human fibroblasts via targeted telomere elongation.
• Senolytic combination of dasatinib and quercetin clears over 90% of senescent cells in aged mice, restoring cardiac and physical function.
• CRISPR-Cas9 editing of longevity-associated genes in mouse models reduces age-related pathology and boosts median lifespan by 15%.

Why it matters: This overview of multi-modal longevity technologies highlights transformative therapies that could redefine healthspan and expand human lifespan.

Researchers at Manipal Academy of Higher Education outline a systematic review protocol to evaluate ML-based AI diagnostic tools for tropical fevers such as dengue, malaria, scrub typhus and chikungunya. They will conduct comprehensive database searches, apply QUADAS-2 for bias assessment, extract TP/TN/FP/FN metrics, and perform meta-analysis using Meta-DiSc and HSROC modeling to pool sensitivity and specificity outcomes.

Key points

• Systematic search across Medline, Embase, Cochrane and Scopus for ML-based diagnostic studies in tropical fevers.
• Dual independent screening with Cohen’s kappa, QUADAS-2 bias assessment and extraction of TP/TN/FP/FN performance metrics.
• Meta-analysis via Meta-DiSc and hierarchical SROC modeling to pool sensitivity, specificity and explore heterogeneity.

Why it matters: Pooling ML-based diagnostic performance metrics for tropical fevers guides development of accurate, scalable AI tools in resource-limited settings.

Maison Santé Clinic offers anti-aging IV therapy using customized infusions of vitamins, minerals, amino acids, and antioxidants delivered intravenously. This approach bypasses the digestive system for rapid cellular uptake, supporting mitochondrial function, reducing oxidative stress, and promoting overall resilience for preventive longevity medicine.

Key points

• Clinical IV infusions deliver high-dose antioxidants like glutathione and vitamin C directly into the bloodstream for cellular repair.
• Customized blends of B-vitamins, amino acids, and magnesium support mitochondrial ATP production and reduce oxidative stress.
• Personalized protocols based on advanced health screenings optimize nutrient dosages for preventive longevity outcomes.

Why it matters: Direct intravenous delivery of key micronutrients offers superior bioavailability and targeted cellular support, marking a new era in preventive longevity medicine.

Nick Bostrom of Oxford’s Future of Humanity Institute articulates a vision where an aligned superintelligence accelerates cures for aging, eradicates scarcity, and builds customizable virtual realities. He discusses philosophical challenges such as preserving human purpose, managing AI governance, and addressing the moral status of digital minds. Bostrom also explores interactions with potential cosmic entities and proposes regulatory frameworks for DNA synthesis and investment models to ensure equitable benefits.

Key points

• Nick Bostrom outlines four Superintelligence challenges: technical alignment, governance, moral status, and cosmic relations.
• Proposes policy measures including global investment models for AI companies and centralized control of DNA synthesis technologies.
• Explores neurotech advances: brain-computer interfaces, whole-brain emulation, and multi-layered safeguards in virtual simulations.