The LEV Foundation initiates RMR2, applying eight damage‐repair interventions to midlife mice with rapamycin baseline and exercise to assess lifespan and healthspan improvements.

Key points

• RMR2 begins mid-life (18–20 months) in C57BL/6J mice with rapamycin baseline and voluntary exercise to assess rejuvenation capacity.
• Eight interventions—including D-PUFAs, recombinant serum albumin, MSCs, partial reprogramming, IL-11 blockade, CASIN, LC-FACS inhibition, and oxytocin—target molecular and cellular aging mechanisms.
• Twenty treatment combinations across male and female cohorts (50 mice each, 2000 total) evaluate lifespan, morbidity, and functional decline metrics.

Why it matters: By testing combined molecular repair interventions in aged mice, RMR2 may reveal synergistic anti‐aging therapies to revolutionize longevity medicine.

Carboncopies Foundation alongside neuroscience and AI research groups detail a stepwise process for whole brain emulation: high-resolution connectome mapping, dynamic activity recording, computational reconstruction, and software-based simulation to achieve digital continuity of mind.

Key points

• High-resolution electron microscopy and AI-driven analysis capture connectomes of small and mammalian brains.
• Functional connectomics integrates structural wiring diagrams with in vivo activity recordings for accurate emulation.
• Two procedural methods—destructive scan-and-copy and non-destructive gradual replacement—are proposed to transfer human consciousness.

Why it matters: Developing whole brain emulation could redefine life extension and AI, unlocking unprecedented insights into consciousness and transforming neuroscience research.

YouthRx, a Chicago-based wellness brand, introduces its Daily Longevity Mix, a curated single-scoop powder that consolidates 19 clinically referenced compounds—ranging from NAD+ precursors and amino acids to antioxidants and vitamins—into a palatable mix. This formula aims to streamline supplement regimens by offering comprehensive cellular energy and structural support within one daily serving.

Key points

• Formulates 19 clinically referenced compounds, including NAD+ precursors and pterostilbene, at research-aligned dosages.
• Delivers comprehensive mitochondrial, structural, and antioxidant support in a single-scoop powder optimized for mixability and flavor.
• Targets multiple aging pathways—cellular energy, collagen synthesis, redox balance—within one daily serving to streamline anti-aging routines.

Why it matters: This all-in-one mix simplifies complex supplement regimens and supports cellular energy, structural integrity, and antioxidant defense within a single daily dose.

PlacidWay’s partner clinics in Colombia deliver anti-aging stem cell therapies for $4,000–$15,000, leveraging autologous or donor-derived mesenchymal cells. The treatment protocol encompasses initial consultations, pre-treatment diagnostics, cell harvesting from adipose or bone marrow sources, processing, and administration by infusion or targeted injections. Comprehensive packages often include post-procedure follow-up, accommodations, and airport transfers. Undertaken by accredited facilities under INVIMA oversight, these therapies aim to regenerate tissues and improve skin quality with minimal downtime.

Key points

• Treatment cost ranges from $4,000 to $15,000, influenced by stem cell type, session count, and clinic reputation.
• Therapies use mesenchymal stem cells harvested autologously from adipose or bone marrow or allogeneically from umbilical cord under GMP.
• Administration occurs via intravenous infusions or localized injections; outcomes include improved skin quality, tissue regeneration, and minimal downtime.

Why it matters: Lower-cost stem cell anti-aging therapies in Colombia democratize access to regenerative medicine, potentially accelerating adoption and improving patient outcomes worldwide.

Researchers at the First Affiliated Hospital of Xinjiang Medical University developed an XGBoost-based ML model using electronic medical records from over 18,000 atrial fibrillation patients to predict in-hospital cardiac mortality. They selected 79 clinical variables, applied downsampling and fivefold cross-validation, and used SHAP for interpretability, achieving high precision, accuracy, and AUC.

Key points

• XGBoost applied to EMR data from 18,727 AF patients achieved AUC 0.964 (training) and 0.932 (validation).
• Data processing included downsampling to balance classes, median imputation for <3% missingness, and removal of highly correlated variables.
• SHAP analysis identified thyroid function indices, procalcitonin, NT-proBNP, and INR as top predictors for in-hospital cardiac mortality.

Why it matters: This interpretable XGBoost model offers precise risk stratification, enabling clinicians to identify high-mortality atrial fibrillation patients and optimize in-hospital interventions.

Researchers at Duke-NUS Medical School introduce FairFML, a model-agnostic framework integrating a fairness penalty into federated learning (FedAvg/Per-FedAvg) to mitigate gender disparities in out-of-hospital cardiac arrest prediction, achieving up to 90% fairness gains with minimal AUC loss.

Key points

• FairFML integrates a convex λ-weighted fairness loss into FedAvg and Per-FedAvg to reduce gender bias by up to 90% in federated cardiac arrest models.
• Validation on 7,425 OHCA episodes partitioned across 4–6 heterogeneous sites shows FairFML maintains predictive AUC within 0.02 of centralized models.
• The model-agnostic framework supports logistic regression to deep learning, offering scalable bias mitigation without sharing raw patient data.

Why it matters: Embedding fairness constraints into federated learning enables equitable AI-driven healthcare delivery across institutions without sacrificing performance.

A research team at Gyeongbuk National University demonstrates that caged European honey bee workers fed undiluted corn syrup exhibit a 26.5-day LT50, outperforming other sugars by enhancing hypopharyngeal gland development, gene expression, and gut microbiome balance to bolster colony resilience.

Key points

• Feeding method: Undiluted corn syrup provided ad libitum to caged Apis mellifera workers.
• Survival metric: Corn syrup group achieved highest LT50 at 26.5 days compared to other carbohydrates.
• Physiological effects: CS increased HPG acini size, upregulated Ilp2 and Vg, and altered gut microbiome diversity.

Why it matters: This work reveals a simple dietary intervention that significantly extends worker bee lifespan and gland function, potentially improving colony resilience.