Seragon Biosciences' preclinical study demonstrates that oral SRN-901 extends remaining lifespan in middle-aged mice by 34.4% through combined mTOR inhibition, autophagy activation, NAD+ enhancement, and senolytic action, while improving endurance, cognition, and reducing tumor incidence.
Key points
- Oral administration of SRN-901 extended remaining lifespan by 34.4% in over 300 middle-aged mice.
- Mechanism involves mTOR inhibition, autophagy activation, NAD+ enhancement, and senolytic stimulation.
- Treatment improved endurance, cognitive function, and reduced tumor incidence and metabolic markers.
Why it matters: This multi-targeted drug marks a shift toward combination aging therapies outperforming rapamycin and opening new avenues for human anti-aging treatments.
Q&A
- What is SRN-901?
- How does mTOR inhibition slow aging?
- What are senolytics and why are they important?
- Why is NAD+ enhancement relevant to longevity?