Researchers at the University of Dundee introduce a precision senolytic platform that selectively identifies and eliminates senescent cells—damaged “zombie” cells that secrete inflammatory factors—to rejuvenate tissue function and mitigate age-related diseases through targeted biomarker profiling and cellular clearance strategies.
Key points
- University of Dundee’s Nature Aging platform uses biomarker-guided senolytic therapies to selectively eliminate senescent cells without collateral tissue damage.
- Clinical data with ABT-263 demonstrate accelerated wound healing and reduced inflammatory SASP factors in aged skin models.
- Precision senolytic approaches reduce systemic inflammatory burden and improve regenerative responses to mitigate age-related pathologies.
Why it matters: Precision senolytics represent a paradigm shift in targeting cellular aging, offering measurable tissue rejuvenation and extended healthspan.
Q&A
- What are senescent cells?
- How do senolytic therapies work?
- What is ABT-263 and how does it aid tissue rejuvenation?
- What are the safety considerations for senolytic treatments?