A team at Shift Bioscience employs a novel single-cell transcriptomic clock (AC3) to screen 1,500 genes, discovering SB000 as a single-factor intervention that reverses transcriptomic and epigenetic aging in fibroblasts and keratinocytes without activating pluripotency, paving the way for safe rejuvenation therapies.

Key points

• AC3 single-cell transcriptomic clock screens 1,500 ORFs to identify rejuvenation factors.
• SB000 expression reduces transcriptomic age by ~4.5 years in fibroblasts and keratinocytes without pluripotency.
• SB000 reverses multiple epigenetic clocks and increases global CpG methylation by ~3%, preserving cell identity.

Why it matters: SB000 decouples cell rejuvenation from pluripotency, offering a safer, single-gene route to reverse aging across diverse tissues.

In a Nature Aging study with over 10,000 participants, researchers used metabolic profiling and randomized trials to evaluate taurine levels as an aging biomarker. They found that declining taurine corresponds to existing health issues, not to the aging process itself, and that supplementation yielded no significant lifespan or healthspan improvements.

Key points

• Large-scale Nature Aging study with 10,000 participants uses metabolomic profiling and RCTs to assess taurine’s role
• Researchers find age-associated taurine decline correlates with comorbidities rather than causal aging factors
• Randomized taurine supplementation shows no significant impact on lifespan or healthspan outcomes

Why it matters: Clarifying taurine’s non-causal link to aging shifts focus toward evidence-based interventions and refines biomarker selection for longevity research.

Klotho Neurosciences has demonstrated that their adeno-associated virus (AAV9) platform delivers the secreted form of the Klotho protein (s-KL) to increase circulating levels, resulting in a 20% extension of healthy lifespan in mice. Building on foundational work linking Klotho to aging, this approach targets multiple age-associated pathologies—including cognitive decline, neuroinflammation, sarcopenia, and osteoporosis—offering a unified therapeutic strategy.

Key points

• AAV9-mediated delivery of secreted Klotho (s-KL) increases mouse lifespan by 20%.
• Overexpression of full-length Klotho gene extends murine lifespan by 30–40%.
• s-KL therapy mitigates cognitive decline, neuroinflammation, sarcopenia, and osteoporosis.

Why it matters: Demonstrating a single protein-based therapy that extends healthy lifespan and ameliorates multiple age-related diseases marks a paradigm shift in anti-aging therapeutics.

Immortal Dragons, a Singapore-based longevity fund founded by Boyang Wang, strategically funds high-risk, high–impact projects. The fund prioritizes replacement-focused approaches—such as xenotransplantation, cryopreservation, and 3D bioprinting—over purely economic returns, aiming to catalyze breakthroughs in healthspan extension and inspire broader sector investment.

Key points

• Immortal Dragons deploys a $40M AUM fund via a flexible CVC model with a single LP, enabling rapid, independent investments free of rigid mandates.
• The fund targets replacement-driven interventions—xenotransplantation, cryopreservation, ex vivo 3D bioprinting of organs and tissues, and neural tissue augmentation—to pursue high-impact anti-aging strategies.
• By emphasizing underfunded, moonshot projects and role-model outliers over blockbuster pharma ventures, the fund seeks to demonstrate lifespan extension potential and catalyze broader capital inflows.

Why it matters: By focusing on replacement-based, high-risk longevity interventions, Immortal Dragons aims to break translational bottlenecks and redefine investment incentives in anti-aging research.

IMR Solutions research demonstrates that integrating AI into ERP systems—via predictive analytics, NLP, and machine learning—yields a 65% reduction in manual processes and anticipates Generation Alpha’s demand for adaptive, context-aware enterprise tools.

Key points

• AI-native ERP in SAP HANA reduces manual processing tasks by 65%
• Predictive analytics, NLP, and machine learning drive adaptive, context-aware workflows
• Implementation delivers a 45% improvement in operational efficiency

Why it matters: AI-enhanced ERP represents a paradigm shift, transforming enterprise software into collaborative partners and giving companies a competitive edge in talent acquisition.