The UCL Institute of Healthy Ageing and the Max Planck Institute for Biology of Ageing demonstrate that combined administration of rapamycin and trametinib extends mouse lifespan by approximately 30% through synergistic modulation of the Ras/Insulin/TOR and ERK signalling networks, also reducing chronic inflammation and tumour onset.

Key points

• Combined rapamycin and trametinib extends mouse lifespan by ~30%.
• Combination therapy reduces chronic inflammation and delays tumour onset in aged mice.
• Transcriptomic analysis reveals unique gene expression changes with combined treatment versus monotherapy.

Why it matters: This synergistic geroprotector combination paradigm offers a powerful approach to delay ageing, reduce inflammation, and prevent cancer more effectively than single agents.

A University of Bologna team applies a penalized logistic regression model to integrate MALDI-TOF species identification and clinical features, accurately forecasting resistance to four antibiotic classes in Gram-negative bloodstream infections.

Key points

• Penalized multivariable logistic regression with nested cross-validation achieved AUROC 0.921±0.013 for carbapenem resistance prediction.
• Integration of MALDI-TOF species identification with demographic and clinical features predicted resistance to fluoroquinolones, 3GC, BL/BLI, and carbapenems.
• Open-source pipeline ResPredAI on GitHub enables local retraining to adapt predictions to specific epidemiology and patient populations.

Why it matters: This AI-driven approach enables early, data-informed empirical therapy decisions, improving patient outcomes and antibiotic stewardship by reducing inappropriate broad-spectrum use.

Pvolve, the clinically backed functional fitness platform, partners with consumer biotech Tally Health to introduce The Longevity Formula - a six-month preventive health program. It combines at-home epigenetic age testing, a curated pro-longevity supplement stack, advanced resistance equipment, and exclusive virtual training sessions. The science-driven bundle tailors functional movement and epigenetic insights to extend healthspan and bolster vitality.

Key points

• The Longevity Formula integrates a six-month pro-longevity supplement stack developed by Tally Health to target metabolic, immune, and cognitive pathways.
• Dual epigenetic age testing provides at-home DNA methylation analysis for tracking cellular aging and personalization.
• Pvolve’s next-generation resistance equipment and on-demand digital membership deliver targeted functional movement coaching and virtual 1:1 sessions.

China’s General Administration of Customs has launched an AI and machine learning‐based system integrating OCR for digitizing inspection and quarantine certificates. It automatically recognizes multiple certificate types, centralizes data validation, and accelerates clearance processes up to ten times faster than manual methods.

Key points

• Integrates OCR, AI, and machine learning to digitize and validate over 100 certificate models.
• Processes more than 286,000 certificates annually, reducing processing times by up to tenfold.
• Centralizes data validation for improved tariff classification accuracy and fraud detection.

Why it matters: By automating certificate digitization and validation, this AI system sets a new standard for efficient, accurate global trade compliance and risk oversight.

E Fund Management, China’s leading mutual fund manager, highlights six sector-specific ETFs—spanning artificial intelligence, robotics & smart devices, cloud computing & big data, biotechnology, new energy and space technology—each tracking CSI indexes to capture growth in China’s technology-driven markets.

Key points

• Top five China tech ETFs collect US$7.87 billion net inflows, led by US$1.17 billion into the AI ETF.
• E Fund highlights six cutting-edge sectors—AI, robotics, cloud computing, biotech, energy and space—via tailored CSI-tracked ETFs.
• Assets under management range from US$489 million in cloud computing to US$2.23 billion in the CSI Artificial Intelligence ETF.

The Dr. John Fortuna Grant, established by a Cleveland-based wellness leader, solicits original essays from healthcare undergraduates and graduates. Applicants outline novel strategies in regenerative medicine aimed at transforming aging into a period of sustained vitality, emphasizing prevention and holistic approaches.

Key points

• Nationwide call for healthcare student essays envisioning regenerative medicine to redefine aging.
• Eligibility requires accredited enrollment, 3.0+ GPA, financial need, transcript, CV, and recommendation letter.
• Focus prompt: creating strategies for extending vitality so 100-year-olds function like 60-year-olds.